Fundamentals of toxicology ERASMUS>KOS03

SUBJECT LEARNING OUTCOMES.

After completing the course and confirming the achievement of the assumed learning outcomes, the student:
- Knows the effects of xenobiotics on the living organism, basic toxicological concepts, factors affecting the toxicity of xenobiotics and possible interactions between xenobiotics.
- Has knowledge about the pathways of absorption, distribution, metabolism and excretion of xenobiotics.
- Knows environmental factors and pollutants that may affect human health, as well as methods of determining their toxicological parameters.
- Has knowledge of the requirements for cosmetic products in terms of their safety.
- Is able to use various sources of information regarding the safety or potential harmful effects of chemicals, including cosmetic preparations and their ingredients.
- Performs calculations related to selected parameters characterizing the toxicity and harmfulness of chemicals, taking into account substances used in cosmetology.
- Is aware of the risks associated with the use of various chemicals, including those present in cosmetic preparations.

PROGRAM CONTENT RELATED TO LEARNING OUTCOMES (including self-study).

Lecture:
1. Basic toxicological concepts.
2. Ways of absorption, distribution, metabolism and excretion of xenobiotics.
3. Factors affecting the toxicity of xenobiotics.
4. Methods of determining toxicity.
5. Safety of cosmetic products.
6. Xenobiotic interactions.

Practical course:
1. Toxic properties of selected chemical compounds.
2. Toxic/harmful properties and safety of selected cosmetic product ingredients.
3. Selected toxicological topics and problems (student papers).
4. Determination of (calculated) LD50 values based on mortality data for different doses.
5. Safety data sheets as the primary source of information on substances included in cosmetic products. MAC of selected cosmetic ingredients.